Payment & Shipping Terms:
|Product Name:||Antidepressant Effect Tianeptine Sulfate||Type:||Antidepressant Effect|
|Application:||Medical||Specification:||1kg/Bag Or 25kg/Drum|
Raw Tianeptine Sulfate Powder,
Antidepressant Nootropics Tianeptine Sulfate,
Tianeptine Sulfate Pharmaceutical Ingredients
There are two main forms of tianeptine: tianeptine sodium and tianeptine sulfate. Both drugs act through the same mechanisms and produce similar results. However, tianeptine sodium has a quicker absorption and excretion rate compared to tianeptine sulfate.
Until recently, the tianeptine’s mechanism of action wasn’t fully understood.
Numerous studies have revealed that tianeptine appears to modulate a variety of neurochemical systems. We’ll delve into these in more detail throughout the article. However, according to current animal models, the main mechanisms of action for tianeptine are:
Direct tianeptine induced activation the mu opioid receptor (MOR).
Enhanced uptake of serotonin by cells.
Regulation of the glutamatergic system in a variety of brain regions. This includes the regulation of glutamate receptor activity within the hippocampus and amygdala.
Modulating glucocorticoid receptors in rodent models of early-life stress.
Upregulating inhibitory GABA expression in the spinal cord.
Regulating hypothalamic-pituitary axis (HPA) and prefrontal cortex activity.
Activating adenosine A1 receptors.
Evidence suggests that tianeptine may also be effective in treating conditions of the peripheral nervous system too, including asthma and irritable bowel syndrome (IBS). This is likely due to the tianeptines ability to modulate the serotoninergic system. Both asthma and IBS are associated with decreased blood-levels of serotonin. Human clinical trials have confirmed tianeptine to be an effective treatment for both of these conditions.
Tianeptine has become controversial due to potentially addictive properties of the compound when taken in large doses.
This primarily suggested due to tianeptine mechanism of action at MOR potentially having similarities with other opioids. Some studies have also reported patients, especially those with a history of substance abuse, experiencing withdrawal and dependence after prolonged use.
However, not all neuropharmacologists agree that tianeptine has a high propensity for addiction and abuse. In fact, there some pharmacologists have expressed that some drugs which are widely prescribed for anxiety at present (such as benzodiazepines) are worse than tianeptine.
There are some animal models which have failed to demonstrate that chronic tianeptine administration leads to tolerance or withdrawal. Additionally, there are many clinical studies which have not reported these addictive effects.
It’s likely that the propensity of the drug to cause addiction may be dependent of the individual. While tianeptine can produce powerful benefits for depression, the compound has now been banned in some regions due to concerns over potential abuse.
|Product Name||Tianeptine Sulfate|
|Shelf Life||24 months when properly stored|
|Storage||Keep in a cool, dry, dark location|
Improves Anxiety and Depression:
Tianeptine is a powerful anti-depressant and anxiolytic drug. These effects have been shown across a variety of human clinical trials, along with animal and cellular studies.
Clinical trials have shown that tianeptine is as effective as classical anti-depressants at treating major depressive disorder. Tianeptine has a particularly high success rate in patients where previous treatments have been ineffective. Moreover, extended treatment with tianeptine appears to decrease the frequency of relapse or reoccurrence of depression.
Similar results have been found in studies which have investigate the usefulness of tianeptine in the treatment of Parkinson’s disease. Patients with Parkinson’s had a significant decrease in the severity of depression symptoms after tianeptine treatment.
Tianeptine has also been shown to be helpful in the treatment of anxiety-related disorders.
For example, one clinical trial showed that tianeptine was able to block the occurrence of panic attacks. Another trial found that tianeptine significantly improved the symptoms of post-traumatic stress disorder (PSTD) patients. The results from these studies are supported by animal model data. In rodent models of PSTD, tianeptine was able to effectively prevent the effects of psychosocial-related stress.
Human clinical trial and animal studies have highlighted that tianeptine administration can reverse or prevent cognitive, learning and memory deficits which are associated with stress, anxiety and depression.
|Appearance||In the N, N - dimethyl formamide dissolved, insoluble in water||Conforms|
|Identification||A .Infrared spectrum should be consistent with the reference spectra||Conforms|
|B. Should show the identification of sulfate reaction||Conforms|
|Related substances||Any impurity ≤0.2%||0.08%|
|Residue on ignition||≤0.1%||0.04%|
|Assay||99.0%-101.0%(On anhydrous basis)||99.56%|
|Conclusion: Conform to the above standards|
SHIPPING & DELIVERY
1. Packages are generally dispatched within approximately 3 days after receipt of payment.
2. we will provide you with a link & tracking number to track your package online. and send the few pictures with your order & details.
3. About the Custom clearance,we packed in disguise ways. We guarantee you safely and fast received the package
4. We confirm 99% clearance, If you can not received the package, we will arrange reshipment to you
If you interested our product, welcome to contact us WhatsApp: +86-188-2175-6359 or you can send details on firstname.lastname@example.org
Contact Person: Hill Zhang