99% Purity SR9011 SARMS Raw Powder CAS 1379686-29-9 Fot Bodybuilding

Bodybuilding Sarms 99% Purity SR9011 Sarm raw Materials Cas 1379686-29-9

What is SR9011 ?

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.

The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

Aliase: SR-9011; 3-(((4-Chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
Purity: 99.9%
Appearance:White fine powder
Brand: ChenFeng
Solubility: DMSO
Storage: 0°C (short term), -20°C (long term), desiccated
Grade: Pharmaceutical Grade

SR-9011 Application:

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

SR-9011 Dosage:

The optimal dosage range is 20 to 30 milligrams (mgs) per day. However, there is a downside - due to the short half-life, you need to exclude the entire day in order to get the best balance of actives in the body. Therefore, it is best to use the anesthetic every 2-4 hours, depending on the exact dose used. For example, at a daily dose of 30 milligrams, take 10 milligrams every 4 hours.

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